Objective To test the efficacy and safety of exercise training among patients with heart failure.ĭesign, Setting, and Patients Multicenter, randomized controlled trial of 2331 medically stable outpatients with heart failure and reduced ejection fraction. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes. Shared Decision Making and CommunicationĪuthor Affiliations: Duke Clinical Research Institute (Drs O’Connor, Whellan, Lee, Ellis, and Schulman and Mr Rendall) and Departments of Medicine (Drs O’Connor, Kraus, and Schulman), Biostatistics and Bioinformatics (Dr Lee), and Psychiatry and Behavioral Sciences (Dr Blumenthal), Duke University School of Medicine, Durham, North Carolina Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania (Dr Whellan) Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, Michigan (Dr Keteyian) Divisions of Prevention and Population Sciences (Drs Cooper and Leifer) and Cardiovascular Diseases (Dr Fleg), National Heart, Lung, and Blood Institute, Bethesda, Maryland Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina (Dr Kitzman) Department of Medicine, Stanford University, Stanford, California (Ms Houston Miller) Hamilton Health Sciences, Hamilton, Ontario, Canada (Dr McKelvie) Centre d’Investigation Clinique, Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire, Université Henri Poincaré, Nancy, France (Dr Zannad) and Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio (Dr Piña).Ĭontext Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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